EP News: Basic and Translational October 6, 2011

Defibrillation with High-Frequency Electric Field

Tandri et al (Sci Transl Med 2011;3:102ra96) studied the effects of electrical stimulation on conduction block in cardiac tissues. Electrical stimulation has been applied to nervous tissue to cause reversible conduction block, but has not been explored sufficiently in cardiac tissue.

The authors show that reversible propagation block can be achieved in cardiac tissue by holding myocardial cells in a refractory state for a designated period of time by applying a sustained sinusoidal high-frequency alternating current (HFAC). In doing so, reentrant arrhythmias are terminated.

(more…)