Recent EP Research: Basic and Translational June 20, 2011
Posted by Peng-Sheng Chen, MD, FHRS in Science & Research.Tags: Long QT Syndrome, LQTS, Ventricular preexcitation
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Using Induced Pluripotent Stem Cells to Investigate Cardiac Phenotypes in Timothy Syndrome
Individuals with long QT syndrome (LQTS) are at risk of life-threatening ventricular arrhythmia. LQTS is commonly genetic in origin but can also be caused or exacerbated by environmental factors. A missense mutation in the L-type calcium channel Ca(V)1.2 leads to LQTS in patients with Timothy syndrome. (more…)
June Science and Research Highlights June 7, 2011
Posted by Peng-Sheng Chen, MD, FHRS in Science & Research.Tags: Brain Pathology, Circulation, Circulation Research, PNAS
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Imaging the electromechanical activity of the heart in vivo
Provost et al (PNAS 2011;108:8565, PMID: 21571641) developed a new method to image electromechanical activity of the heart in vivo. Cardiac conduction abnormalities remain a major cause of death and disability worldwide. However, there is no standard clinical imaging modality that can noninvasively map the electrical activation. (more…)
Basic and Translational Research May 20, 2011
Posted by Peng-Sheng Chen, MD, FHRS in Science & Research.Tags: Cardiovascular Research Journal, Circulation Research Journal, European Heart Journal, Journal of Pharmacology and Experimental Therapeutics, Journal of Physiology
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Upregulation of ventricular potassium channels by chronic tamoxifen treatment
Tamoxifen is a selective estrogen receptor modulator widely used in the prevention and treatment of breast cancer. Although acute perfusion of tamoxifen has been shown to inhibit cardiac K(+) currents, women receiving long term tamoxifen therapy do not have increased arrhythmia. (more…)
New Treatments for Vasovagal Syncope May 16, 2011
Posted by Peng-Sheng Chen, MD, FHRS in Science & Research, Scientific Sessions.Tags: Heart Rhythm 2011
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Many interesting basic-translational science abstracts were presented during the Heart Rhythm Society’s 32nd Annual Scientific Sessions. The following two abstracts provide new hope for breakthrough treatment of the vasovagal syncope (VVS), a major clinical problem for EP consultants. (more…)
Basic and Translational Research from Heart Rhythm Journal April 4, 2011
Posted by Peng-Sheng Chen, MD, FHRS in Science & Research.Tags: Circulation Journal, Circulation Research, Nature Genetics
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Modeling the Long QT Syndrome with Induced Pluripotent Stem Cells
The ability to generate patient-specific human induced pluripotent stem cells (iPSCs) offers a new paradigm for modeling human disease and for individualizing drug testing.
Congenital long QT syndrome (LQTS) is a familial arrhythmogenic syndrome characterized by abnormal ion channel function and sudden cardiac death. Itzhaki et al (Nature 2011; Epub; PMID: 21240260) report the development of a patient/disease-specific human iPSC line from a patient with type-2 long QT syndrome (LQTS) due to the A614V missense mutation in the KCNH2 gene. (more…)
Basic and Translational Research from Heart Rhythm Journal March 23, 2011
Posted by Peng-Sheng Chen, MD, FHRS in Science & Research.Tags: AF, Atrial fibrillation
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Autonomic Denervation with Magnetic Nanoparticles
Ganglionated plexi (GP) are important in the initiation of atrial fibrillation. Yu et al (Circulation 2010;122:2653, PMID: 21135360) reported a new method of autonomic denervation using nanoparticles. The authors synthesized superparamagnetic nanoparticles (MNPs) made of Fe3O4 (core), thermoresponsive polymeric hydrogel (shell), and neurotoxic agent (N-isopropylacrylamide monomer [NIPA-M]). (more…)
RGS6 and Parasympathetic Modulation of the Heart Rate February 1, 2011
Posted by Peng-Sheng Chen, MD, FHRS in Science & Research.Tags: G protein, RGS6
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Parasympathetic regulation of heart rate is mediated by acetylcholine binding to G protein-coupled muscarinic M2 receptors, which activate heterotrimeric G(i/o) proteins to promote G protein-coupled inwardly rectifying K+ (GIRK) channel activation. (more…)
Ephaptic Coupling and Electrical Conduction January 13, 2011
Posted by Peng-Sheng Chen, MD, FHRS in Scientific Sessions.Tags: Ephaptic coupling, Junctional coupling
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While gap junctional coupling is usually considered to be the primary mechanism for action potential propagation, there is evidence that other mechanisms are also important. (more…)
Structure and Function of Ryanodine Receptors December 13, 2010
Posted by Peng-Sheng Chen, MD, FHRS in Science & Research.Tags: Ryanodine receptors
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Two recent articles reported important findings about the structure and function of the ryanodine receptors (RyRs). (more…)
Research: Patient-Specific Stem-Cell Models for Long-QT Syndrome September 3, 2010
Posted by Peng-Sheng Chen, MD, FHRS in Science & Research.Tags: Long-QT syndrome type 1, Tachyarrhythmia
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Patient-Specific Stem-Cell Models for Long-QT Syndrome
Moretti et al (NEJM 2010; Epub, PMID: 20660394) screened a family affected by long-QT syndrome type 1 (LQT1) and identified an autosomal dominant missense mutation (R190Q) in the KCNQ1 gene. (more…)
Heart Rhythm Society
Laurie Racenet, RN, MSN, ANP
Michael Giudici, MD, FACC, FACP, FHRS
Heather M. Ross, DNP, ANP-BC, CCDS, CEPS, FHRS
Anne Dubin, MD, FHRS
John D. Day, MD, FHRS
Andrea M. Russo, MD, FACC, FHRS
Joshua M. Cooper, MD, FACC
Amit J. Shanker, MD, FHRS, FACC
Bruce Stambler, MD
David Wiggins, RN, BS BME, CEPS
Fred M. Kusumoto, MD, FHRS
Leonard Ganz, MD, FHRS
christinechiuman
Craig Delaughter, MD, PhD
Ariana Del Negro, Heart Rhythm 2010 Quality
Peng-Sheng Chen, MD, FHRS
MSKremers MD,FHRS
Ann C. Garlitski, MD, FACC, FHRS
Alan Cheng, MD, FHRS
Ulrika Birgersdotter-Green, MD
Christopher Clyne, MD, FHRS
Kathleen Blake, MD, MPH, FHRS
David Scher, MD, FHRS
Sanjay Deshpande, MD, FHRS
Thomas F. Deering, MD, FHRS
